Cathepsin D deficiency in mammary epithelium transiently stalls breast cancer by interference with mTORC1 signaling

Cathepsin D (CTSD) is a lysosomal protease and a marker of poor prognosis in breast cancer. However, the cells responsible for this association and the function of CTSD in cancer are still incompletely understood. By using a conditional CTSD knockout mouse crossed to the transgenic MMTV-PyMT breast...

Descripción completa

Detalles Bibliográficos
Autores principales: Ketterer, Stephanie, Mitschke, Julia, Ketscher, Anett, Schlimpert, Manuel, Reichardt, Wilfried, Baeuerle, Natascha, Hess, Maria Elena, Metzger, Patrick, Boerries, Melanie, Peters, Christoph, Kammerer, Bernd, Brummer, Tilman, Steinberg, Florian, Reinheckel, Thomas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552405/
https://www.ncbi.nlm.nih.gov/pubmed/33046706
http://dx.doi.org/10.1038/s41467-020-18935-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552405/
https://www.ncbi.nlm.nih.gov/pubmed/33046706
http://dx.doi.org/10.1038/s41467-020-18935-2

Ejemplares similares