Inhibition of O-GlcNAc transferase activates tumor-suppressor gene expression in tamoxifen-resistant breast cancer cells

In this study, we probed the importance of O-GlcNAc transferase (OGT) activity for the survival of tamoxifen-sensitive (TamS) and tamoxifen-resistant (TamR) breast cancer cells. Tamoxifen is an antagonist of estrogen receptor (ERα), a transcription factor expressed in over 50% of breast cancers. ERα...

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Detalles Bibliográficos
Autores principales: Barkovskaya, Anna, Seip, Kotryna, Prasmickaite, Lina, Mills, Ian G., Moestue, Siver A., Itkonen, Harri M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552408/
https://www.ncbi.nlm.nih.gov/pubmed/33046784
http://dx.doi.org/10.1038/s41598-020-74083-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552408/
https://www.ncbi.nlm.nih.gov/pubmed/33046784
http://dx.doi.org/10.1038/s41598-020-74083-z

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