Novel insights into extrachromosomal DNA: redefining the onco-drivers of tumor progression

Extrachromosomal DNA (ecDNA), gene-encoding extrachromosomal particles of DNA, is often present in tumor cells. Recent studies have revealed that oncogene amplification via ecDNA is widespread across a diverse range of cancers. ecDNA is involved in increasing tumor heterogeneity, reverting tumor phe...

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Detalles Bibliográficos
Autores principales: Gu, Xiang, Yu, Jie, Chai, Peiwei, Ge, Shengfang, Fan, Xianqun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552444/
https://www.ncbi.nlm.nih.gov/pubmed/33046109
http://dx.doi.org/10.1186/s13046-020-01726-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552444/
https://www.ncbi.nlm.nih.gov/pubmed/33046109
http://dx.doi.org/10.1186/s13046-020-01726-4

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