Breast cancer-induced immune suppression in the sentinel lymph node is effectively countered by CpG-B in conjunction with inhibition of the JAK2/STAT3 pathway

BACKGROUND: We previously showed selectively hampered activation of lymph node-resident (LNR) dendritic cell (DC) subsets in the breast cancer (BrC) sentinel lymph node (SLN) to precede a state of profound T cell anergy. Reactivating these DC subsets by intratumoral delivery of the Toll-like recepto...

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Detalles Bibliográficos
Autores principales: van Pul, Kim M, Vuylsteke, Ronald J C L M, de Beijer, Monique T A, van de Ven, Rieneke, van den Tol, M Petrousjka, Stockmann, Hein B A C, de Gruijl, Tanja D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2020
Materias:
Basic Tumor Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552844/
https://www.ncbi.nlm.nih.gov/pubmed/33046620
http://dx.doi.org/10.1136/jitc-2020-000761

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7552844/
https://www.ncbi.nlm.nih.gov/pubmed/33046620
http://dx.doi.org/10.1136/jitc-2020-000761

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