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Room-temperature X-ray crystallography reveals the oxidation and reactivity of cysteine residues in SARS-CoV-2 3CL M(pro): insights into enzyme mechanism and drug design
The emergence of the novel coronavirus SARS-CoV-2 has resulted in a worldwide pandemic not seen in generations. Creating treatments and vaccines to battle COVID-19, the disease caused by the virus, is of paramount importance in order to stop its spread and save lives. The viral main protease, 3CL M(...
Autores principales: | Kneller, Daniel W., Phillips, Gwyndalyn, O’Neill, Hugh M., Tan, Kemin, Joachimiak, Andrzej, Coates, Leighton, Kovalevsky, Andrey |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
International Union of Crystallography
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553146/ https://www.ncbi.nlm.nih.gov/pubmed/33063790 http://dx.doi.org/10.1107/S2052252520012634 |
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