Single Nucleotide Resolution Analysis Reveals Pervasive, Long-Lasting DNA Methylation Changes by Developmental Exposure to a Mitochondrial Toxicant

Mitochondrial-driven alterations of the epigenome have been reported, but whether they are relevant at the organismal level remains unknown. The viable yellow agouti mouse (A(vy)) is a powerful epigenetic biosensor model that reports on the DNA methylation status of the A(vy) locus, which is establi...

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Detalles Bibliográficos
Autores principales: Lozoya, Oswaldo A., Xu, Fuhua, Grenet, Dagoberto, Wang, Tianyuan, Grimm, Sara A., Godfrey, Veronica, Waidyanatha, Suramya, Woychik, Richard P., Santos, Janine H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553240/
https://www.ncbi.nlm.nih.gov/pubmed/32937126
http://dx.doi.org/10.1016/j.celrep.2020.108131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553240/
https://www.ncbi.nlm.nih.gov/pubmed/32937126
http://dx.doi.org/10.1016/j.celrep.2020.108131

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