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Single Nucleotide Resolution Analysis Reveals Pervasive, Long-Lasting DNA Methylation Changes by Developmental Exposure to a Mitochondrial Toxicant
Mitochondrial-driven alterations of the epigenome have been reported, but whether they are relevant at the organismal level remains unknown. The viable yellow agouti mouse (A(vy)) is a powerful epigenetic biosensor model that reports on the DNA methylation status of the A(vy) locus, which is establi...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553240/ https://www.ncbi.nlm.nih.gov/pubmed/32937126 http://dx.doi.org/10.1016/j.celrep.2020.108131 |