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Penalized regression and model selection methods for polygenic scores on summary statistics
Polygenic scores quantify the genetic risk associated with a given phenotype and are widely used to predict the risk of complex diseases. There has been recent interest in developing methods to construct polygenic risk scores using summary statistic data. We propose a method to construct polygenic r...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553329/ https://www.ncbi.nlm.nih.gov/pubmed/33001975 http://dx.doi.org/10.1371/journal.pcbi.1008271 |