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Exploring the sequence fitness landscape of a bridge between protein folds

Most foldable protein sequences adopt only a single native fold. Recent protein design studies have, however, created protein sequences which fold into different structures apon changes of environment, or single point mutation, the best characterized example being the switch between the folds of the...

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Detalles Bibliográficos
Autores principales: Tian, Pengfei, Best, Robert B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553338/
https://www.ncbi.nlm.nih.gov/pubmed/33048928
http://dx.doi.org/10.1371/journal.pcbi.1008285