Immunogenicity and antitumor efficacy of a novel human PD-1 B-cell vaccine (PD1-Vaxx) and combination immunotherapy with dual trastuzumab/pertuzumab-like HER-2 B-cell epitope vaccines (B-Vaxx) in a syngeneic mouse model

Therapeutic blockade of PD-1/PD-L1 signaling with monoclonal antibodies (mAbs) has shown clinical success and activity across a broad set of cancer subtypes. However, monotherapy with PD-1/PD-L1 inhibitors are only effective in a subset of patients and ongoing studies show efficacy of treatment depe...

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Detalles Bibliográficos
Autores principales: Kaumaya, Pravin T. P., Guo, Linlin, Overholser, Jay, Penichet, Manuel L., Bekaii-Saab, Tanios
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553530/
https://www.ncbi.nlm.nih.gov/pubmed/33117602
http://dx.doi.org/10.1080/2162402X.2020.1818437

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553530/
https://www.ncbi.nlm.nih.gov/pubmed/33117602
http://dx.doi.org/10.1080/2162402X.2020.1818437

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