KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2

Krüppel-like factor 5 (KLF5) can both promote and suppress cell migration, but the underlying mechanisms have not been elucidated. In this study, we show that the function of KLF5 in epithelial-mesenchymal transition (EMT) and migration of liver cancer cells depends on the status of the cellular tum...

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Autores principales: Sun, Lan, Zhou, Xiaona, Li, Yanmeng, Chen, Wei, Wu, Shanna, Zhang, Bei, Yao, Jingyi, Xu, Anjian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553557/
https://www.ncbi.nlm.nih.gov/pubmed/32965165
http://dx.doi.org/10.1080/19336918.2020.1826216
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author Sun, Lan
Zhou, Xiaona
Li, Yanmeng
Chen, Wei
Wu, Shanna
Zhang, Bei
Yao, Jingyi
Xu, Anjian
author_facet Sun, Lan
Zhou, Xiaona
Li, Yanmeng
Chen, Wei
Wu, Shanna
Zhang, Bei
Yao, Jingyi
Xu, Anjian
author_sort Sun, Lan
collection PubMed
description Krüppel-like factor 5 (KLF5) can both promote and suppress cell migration, but the underlying mechanisms have not been elucidated. In this study, we show that the function of KLF5 in epithelial-mesenchymal transition (EMT) and migration of liver cancer cells depends on the status of the cellular tumor antigen p53 (p53). Furthermore, zinc finger E-box-binding homeobox 2 (ZEB2) is the main regulator of KLF5 in EMT in liver cancer cells in the context of p53 loss. Most importantly, the regulation of ZEB2 by p53 and KLF5 is indirect and that miR-192 mediates this regulation. Finally, we find that in invasive liver cancer, KLF5 is absent in the context of p53 loss or mutation.
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spelling pubmed-75535572020-10-23 KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2 Sun, Lan Zhou, Xiaona Li, Yanmeng Chen, Wei Wu, Shanna Zhang, Bei Yao, Jingyi Xu, Anjian Cell Adh Migr Research Paper Krüppel-like factor 5 (KLF5) can both promote and suppress cell migration, but the underlying mechanisms have not been elucidated. In this study, we show that the function of KLF5 in epithelial-mesenchymal transition (EMT) and migration of liver cancer cells depends on the status of the cellular tumor antigen p53 (p53). Furthermore, zinc finger E-box-binding homeobox 2 (ZEB2) is the main regulator of KLF5 in EMT in liver cancer cells in the context of p53 loss. Most importantly, the regulation of ZEB2 by p53 and KLF5 is indirect and that miR-192 mediates this regulation. Finally, we find that in invasive liver cancer, KLF5 is absent in the context of p53 loss or mutation. Taylor & Francis 2020-10-07 /pmc/articles/PMC7553557/ /pubmed/32965165 http://dx.doi.org/10.1080/19336918.2020.1826216 Text en © 2020 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group. https://creativecommons.org/licenses/by/4.0/This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Paper
Sun, Lan
Zhou, Xiaona
Li, Yanmeng
Chen, Wei
Wu, Shanna
Zhang, Bei
Yao, Jingyi
Xu, Anjian
KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2
title KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2
title_full KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2
title_fullStr KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2
title_full_unstemmed KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2
title_short KLF5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through miR-192 targeting of ZEB2
title_sort klf5 regulates epithelial-mesenchymal transition of liver cancer cells in the context of p53 loss through mir-192 targeting of zeb2
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553557/
https://www.ncbi.nlm.nih.gov/pubmed/32965165
http://dx.doi.org/10.1080/19336918.2020.1826216
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