Dynamics of nevus development implicate cell cooperation in the growth arrest of transformed melanocytes

Mutational activation of the BRAF proto-oncogene in melanocytes reliably produces benign nevi (pigmented ‘moles’), yet the same change is the most common driver mutation in melanoma. The reason nevi stop growing, and do not progress to melanoma, is widely attributed to a cell-autonomous process of ‘...

Descripción completa

Detalles Bibliográficos
Autores principales: Ruiz-Vega, Rolando, Chen, Chi-Fen, Razzak, Emaad, Vasudeva, Priya, Krasieva, Tatiana B, Shiu, Jessica, Caldwell, Michael G, Yan, Huaming, Lowengrub, John, Ganesan, Anand K, Lander, Arthur D
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553774/
https://www.ncbi.nlm.nih.gov/pubmed/33047672
http://dx.doi.org/10.7554/eLife.61026

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553774/
https://www.ncbi.nlm.nih.gov/pubmed/33047672
http://dx.doi.org/10.7554/eLife.61026

Ejemplares similares