Structural insights into human acid-sensing ion channel 1a inhibition by snake toxin mambalgin1

Acid-sensing ion channels (ASICs) are proton-gated cation channels that are involved in diverse neuronal processes including pain sensing. The peptide toxin Mambalgin1 (Mamba1) from black mamba snake venom can reversibly inhibit the conductance of ASICs, causing an analgesic effect. However, the det...

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Detalles Bibliográficos
Autores principales: Sun, Demeng, Liu, Sanling, Li, Siyu, Zhang, Mengge, Yang, Fan, Wen, Ming, Shi, Pan, Wang, Tao, Pan, Man, Chang, Shenghai, Zhang, Xing, Zhang, Longhua, Tian, Changlin, Liu, Lei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Structural Biology and Molecular Biophysics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553779/
https://www.ncbi.nlm.nih.gov/pubmed/32915133
http://dx.doi.org/10.7554/eLife.57096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553779/
https://www.ncbi.nlm.nih.gov/pubmed/32915133
http://dx.doi.org/10.7554/eLife.57096

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