Computational analysis of TP53 mutational landscape unveils key prognostic signatures and distinct pathobiological pathways in head and neck squamous cell cancer

BACKGROUND: Mutations of the tumour-suppressor gene TP53 are the most frequent somatic genomic alterations in head and neck squamous cell carcinoma (HNSCC). However, it is not yet clear whether specific TP53 mutations bear distinct clinical and pathophysiological significance in different HNSCC subg...

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Detalles Bibliográficos
Autores principales: Caponio, Vito Carlo Alberto, Troiano, Giuseppe, Adipietro, Iolanda, Zhurakivska, Khrystyna, Arena, Claudia, Mangieri, Domenica, Mascitti, Marco, Cirillo, Nicola, Lo Muzio, Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553957/
https://www.ncbi.nlm.nih.gov/pubmed/32684626
http://dx.doi.org/10.1038/s41416-020-0984-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7553957/
https://www.ncbi.nlm.nih.gov/pubmed/32684626
http://dx.doi.org/10.1038/s41416-020-0984-6

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