Cargando…

PERK controls bone homeostasis through the regulation of osteoclast differentiation and function

Osteoclasts are multinucleated giant cells with the ability to degrade bone tissue, and are closely related to abnormal bone metabolic diseases. Endoplasmic reticulum (ER) is an organelle responsible for protein modification, quality control, and transportation. The accumulation of unfolded or misfo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Guo, Jiachao, Ren, Ranyue, Sun, Kai, Yao, Xudong, Lin, Jiamin, Wang, Genchun, Guo, Zhou, Xu, Tao, Guo, Fengjing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554039/ https://www.ncbi.nlm.nih.gov/pubmed/33051453 http://dx.doi.org/10.1038/s41419-020-03046-z

Ejemplares similares

PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission
por: Guo, Jiachao, et al.
Publicado: (2020)

PERK signaling pathway in bone metabolism: Friend or foe?
por: Guo, Jiachao, et al.
Publicado: (2021)

Astaxanthin protects against osteoarthritis via Nrf2: a guardian of cartilage homeostasis
por: Sun, Kai, et al.
Publicado: (2019)

Deferoxamine Alleviates Osteoarthritis by Inhibiting Chondrocyte Ferroptosis and Activating the Nrf2 Pathway
por: Guo, Zhou, et al.
Publicado: (2022)

Corrigendum: Deferoxamine alleviates osteoarthritis by inhibiting chondrocyte ferroptosis and activating the Nrf2 pathway
por: Guo, Zhou, et al.
Publicado: (2023)

Chondrocyte ferroptosis contribute to the progression of osteoarthritis
por: Yao, Xudong, et al.
Publicado: (2020)

Growth differentiation factor 5 in cartilage and osteoarthritis: A possible therapeutic candidate
por: Sun, Kai, et al.
Publicado: (2021)

Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR
por: Guo, Jiachao, et al.
Publicado: (2017)

Corrigendum: Meclizine Prevents Ovariectomy-Induced Bone Loss and Inhibits Osteoclastogenesis Partially by Upregulating PXR
por: Guo, Jiachao, et al.
Publicado: (2018)

DJ-1 controls bone homeostasis through the regulation of osteoclast differentiation
por: Kim, Hyuk Soon, et al.
Publicado: (2017)

Icariin Protects Bone Marrow Mesenchymal Stem Cells Against Iron Overload Induced Dysfunction Through Mitochondrial Fusion and Fission, PI3K/AKT/mTOR and MAPK Pathways
por: Yao, Xudong, et al.
Publicado: (2019)

Mitophagy in degenerative joint diseases
por: Sun, Kai, et al.
Publicado: (2020)

PTEN inhibitor VO-OHpic attenuates GC-associated endothelial progenitor cell dysfunction and osteonecrosis of the femoral head via activating Nrf2 signaling and inhibiting mitochondrial apoptosis pathway
por: Yao, Xudong, et al.
Publicado: (2020)

Protocadherin-7 contributes to maintenance of bone homeostasis through regulation of osteoclast multinucleation
por: Kim, Hyunsoo, et al.
Publicado: (2020)

The Blimp1–Bcl6 axis is critical to regulate osteoclast differentiation and bone homeostasis
por: Miyauchi, Yoshiteru, et al.
Publicado: (2010)

Osteoblast-Osteoclast Communication and Bone Homeostasis
por: Kim, Jung-Min, et al.
Publicado: (2020)

Mitoquinone alleviates osteoarthritis progress by activating the NRF2-Parkin axis
por: Hou, Liangcai, et al.
Publicado: (2023)

Lipid peroxidation in osteoarthritis: focusing on 4-hydroxynonenal, malondialdehyde, and ferroptosis
por: Zhang, Xiong, et al.
Publicado: (2023)

The role of Ca(2+)/Calcineurin/NFAT signalling pathway in osteoblastogenesis
por: Ren, Ranyue, et al.
Publicado: (2021)

PIP5k1β controls bone homeostasis through modulating both osteoclast and osteoblast differentiation
por: Zhao, Xiaoying, et al.
Publicado: (2019)

BRCA1 mediates protein homeostasis through the ubiquitination of PERK and IRE1
por: Hromas, Robert, et al.
Publicado: (2022)

Bone loss: Factors that regulate osteoclast differentiation - an update
por: Roux, Sophie, et al.
Publicado: (2000)

Hypoxic regulation of osteoclast differentiation and bone resorption activity
por: Knowles, Helen J
Publicado: (2015)

Bone morphogenetic proteins: Their role in regulating osteoclast differentiation
por: Huntley, Raphael, et al.
Publicado: (2019)

The KDM4B–CCAR1–MED1 axis is a critical regulator of osteoclast differentiation and bone homeostasis
por: Yi, Sun-Ju, et al.
Publicado: (2021)

Oxysterols and EBI2 promote osteoclast precursor migration to bone surfaces and regulate bone mass homeostasis
por: Nevius, Erin, et al.
Publicado: (2015)

BMP-IHH-mediated interplay between mesenchymal stem cells and osteoclasts supports calvarial bone homeostasis and repair
por: Guo, Yuxing, et al.
Publicado: (2018)

Inhibition of TRADD ameliorates chondrocyte necroptosis and osteoarthritis by blocking RIPK1-TAK1 pathway and restoring autophagy
por: Sun, Kai, et al.
Publicado: (2023)

Regulation of TNF-Induced Osteoclast Differentiation
por: Yao, Zhenqiang, et al.
Publicado: (2021)

Perk Gene Dosage Regulates Glucose Homeostasis by Modulating Pancreatic β-Cell Functions
por: Wang, Rong, et al.
Publicado: (2014)

Tocotrienols Regulate Bone Loss through Suppression on Osteoclast Differentiation and Activity: A Systematic Review
por: Radzi, Nur Fathiah Mohd, et al.
Publicado: (2018)

Effect of Taraxaci Herba on Bone Loss in an OVX-Induced Model through the Regulation of Osteoclast Differentiation
por: Heo, Jun, et al.
Publicado: (2022)

Mechanical sensing protein PIEZO1 regulates bone homeostasis via osteoblast-osteoclast crosstalk
por: Wang, Lijun, et al.
Publicado: (2020)

Nucleic acid direct delivery to fibroblasts: a review of nucleofection and applications
por: Ren, Ranyue, et al.
Publicado: (2022)

Osteoclast differentiation and dynamic mRNA expression during mice embryonic palatal bone development
por: Lai, Yongzhen, et al.
Publicado: (2023)

CLEC5A is critical for dengue virus-induced osteoclast activation and bone homeostasis
por: Huang, Ya-Lang, et al.
Publicado: (2016)

Erk1 Positively Regulates Osteoclast Differentiation and Bone Resorptive Activity
por: He, Yongzheng, et al.
Publicado: (2011)

ELMO1 Regulates RANKL-Stimulated Differentiation and Bone Resorption of Osteoclasts
por: Liang, Xinyue, et al.
Publicado: (2021)

Potential Role of Rebamipide in Osteoclast Differentiation and Mandibular Condylar Cartilage Homeostasis
por: Izawa, Takashi, et al.
Publicado: (2018)

Poncirin Inhibits Osteoclast Differentiation and Bone Loss through Down-Regulation of NFATc1 In Vitro and In Vivo
por: Chun, Kwang-Hoon, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_9c7lafk09154rp3ihe6g6vh6kl