CTCF orchestrates long-range cohesin-driven V(D)J recombinational scanning

RAG endonuclease initiates V(D)J recombination in progenitor (pro)-B cells(1). Upon binding a recombination center (RC)-based J(H), RAG scans upstream chromatin via loop extrusion, potentially mediated by cohesin, to locate Ds and assemble a DJ(H)-based RC(2). CTCF looping factor-bound elements (CBE...

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Detalles Bibliográficos
Autores principales: Ba, Zhaoqing, Lou, Jiangman, Ye, Adam Yongxin, Dai, Hai-Qiang, Dring, Edward W., Lin, Sherry G., Jain, Suvi, Kyritsis, Nia, Kieffer-Kwon, Kyong-Rim, Casellas, Rafael, Alt, Frederick W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554077/
https://www.ncbi.nlm.nih.gov/pubmed/32717742
http://dx.doi.org/10.1038/s41586-020-2578-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554077/
https://www.ncbi.nlm.nih.gov/pubmed/32717742
http://dx.doi.org/10.1038/s41586-020-2578-0

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