Concentration-dependent splicing is enabled by Rbfox motifs of intermediate affinity

The Rbfox family of splicing factors regulate alternative splicing during animal development and in disease, impacting thousands of exons in the maturing brain, heart, and muscle. Rbfox proteins have long been known to bind to the RNA sequence GCAUG with high affinity, but just half of Rbfox binding...

Descripción completa

Detalles Bibliográficos
Autores principales: Begg, Bridget E., Jens, Marvin, Wang, Peter Y., Minor, Christine M., Burge, Christopher B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554199/
https://www.ncbi.nlm.nih.gov/pubmed/32807990
http://dx.doi.org/10.1038/s41594-020-0475-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554199/
https://www.ncbi.nlm.nih.gov/pubmed/32807990
http://dx.doi.org/10.1038/s41594-020-0475-8

Ejemplares similares