Targeting Methionine Synthase in a Fungal Pathogen Causes a Metabolic Imbalance That Impacts Cell Energetics, Growth, and Virulence

There is an urgent need to develop novel antifungals to tackle the threat fungal pathogens pose to human health. Here, we have performed a comprehensive characterization and validation of the promising target methionine synthase (MetH). We show that in Aspergillus fumigatus the absence of this enzym...

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Detalles Bibliográficos
Autores principales: Scott, Jennifer, Sueiro-Olivares, Monica, Thornton, Benjamin P., Owens, Rebecca A., Muhamadali, Howbeer, Fortune-Grant, Rachael, Thomson, Darren, Thomas, Riba, Hollywood, Katherine, Doyle, Sean, Goodacre, Royston, Tabernero, Lydia, Bignell, Elaine, Amich, Jorge
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554668/
https://www.ncbi.nlm.nih.gov/pubmed/33051366
http://dx.doi.org/10.1128/mBio.01985-20

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554668/
https://www.ncbi.nlm.nih.gov/pubmed/33051366
http://dx.doi.org/10.1128/mBio.01985-20

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