Develop a High-Throughput Screening Method to Identify C-P4H1 (Collagen Prolyl 4-Hydroxylase 1) Inhibitors from FDA-Approved Chemicals

Collagen prolyl 4-hydroxylase 1 (C-P4H1) is an α-ketoglutarate (α-KG)-dependent dioxygenase that catalyzes 4-hydroxylation of proline on collagen. C-P4H1-induced prolyl hydroxylation is required for proper collagen deposition and cancer metastasis. Therefore, targeting C-P4H1 is considered a potenti...

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Detalles Bibliográficos
Autores principales: Wang, Shike, Lee, Kuo-Hao, Araujo, Nathalia Victoria, Zhan, Chang-Guo, Rangnekar, Vivek M., Xu, Ren
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554770/
https://www.ncbi.nlm.nih.gov/pubmed/32927660
http://dx.doi.org/10.3390/ijms21186613

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554770/
https://www.ncbi.nlm.nih.gov/pubmed/32927660
http://dx.doi.org/10.3390/ijms21186613

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