The Catalytic Cycle of the Antioxidant and Cancer-Associated Human NQO1 Enzyme: Hydride Transfer, Conformational Dynamics and Functional Cooperativity

Human NQO1 [NAD(H):quinone oxidoreductase 1] is a multi-functional and stress-inducible dimeric protein involved in the antioxidant defense, the activation of cancer prodrugs and the stabilization of oncosuppressors. Despite its roles in human diseases, such as cancer and neurological disorders, a d...

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Detalles Bibliográficos
Autores principales: Anoz-Carbonell, Ernesto, Timson, David J., Pey, Angel L., Medina, Milagros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554937/
https://www.ncbi.nlm.nih.gov/pubmed/32825392
http://dx.doi.org/10.3390/antiox9090772

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554937/
https://www.ncbi.nlm.nih.gov/pubmed/32825392
http://dx.doi.org/10.3390/antiox9090772

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