BAY 41-2272 Attenuates CTGF Expression via sGC/cGMP-Independent Pathway in TGFβ1-Activated Hepatic Stellate Cells

Activation of hepatic stellate cells (HSCs) is a critical pathogenic feature of liver fibrosis and cirrhosis. BAY 41-2272 is a canonical non-nitric oxide (NO)-based soluble guanylyl cyclase (sGC) stimulator that triggers cyclic guanosine monophosphate (cGMP) signaling for attenuation of fibrotic dis...

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Detalles Bibliográficos
Autores principales: Chen, Po-Jen, Kuo, Liang-Mou, Wu, Yi-Hsiu, Chang, Yu-Chia, Lai, Kuei-Hung, Hwang, Tsong-Long
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554962/
https://www.ncbi.nlm.nih.gov/pubmed/32899801
http://dx.doi.org/10.3390/biomedicines8090330

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7554962/
https://www.ncbi.nlm.nih.gov/pubmed/32899801
http://dx.doi.org/10.3390/biomedicines8090330

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