Methods Favoring Homology-Directed Repair Choice in Response to CRISPR/Cas9 Induced-Double Strand Breaks

Precise gene editing is—or will soon be—in clinical use for several diseases, and more applications are under development. The programmable nuclease Cas9, directed by a single-guide RNA (sgRNA), can introduce double-strand breaks (DSBs) in target sites of genomic DNA, which constitutes the initial s...

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Detalles Bibliográficos
Autores principales: Yang, Han, Ren, Shuling, Yu, Siyuan, Pan, Haifeng, Li, Tingdong, Ge, Shengxiang, Zhang, Jun, Xia, Ningshao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555059/
https://www.ncbi.nlm.nih.gov/pubmed/32899704
http://dx.doi.org/10.3390/ijms21186461

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555059/
https://www.ncbi.nlm.nih.gov/pubmed/32899704
http://dx.doi.org/10.3390/ijms21186461

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