Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis?

In this review, we summarize the evidence against direct stimulation of insulin-like growth factor 1 receptors (IGF1Rs) by autoantibodies in Graves’ orbitopathy (GO) pathogenesis. We describe a model of thyroid-stimulating hormone (TSH) receptor (TSHR)/IGF1R crosstalk and present evidence that obser...

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Detalles Bibliográficos
Autores principales: Krieger, Christine C., Neumann, Susanne, Gershengorn, Marvin C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555308/
https://www.ncbi.nlm.nih.gov/pubmed/32911689
http://dx.doi.org/10.3390/ijms21186561

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555308/
https://www.ncbi.nlm.nih.gov/pubmed/32911689
http://dx.doi.org/10.3390/ijms21186561

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