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Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis?
In this review, we summarize the evidence against direct stimulation of insulin-like growth factor 1 receptors (IGF1Rs) by autoantibodies in Graves’ orbitopathy (GO) pathogenesis. We describe a model of thyroid-stimulating hormone (TSH) receptor (TSHR)/IGF1R crosstalk and present evidence that obser...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555308/ https://www.ncbi.nlm.nih.gov/pubmed/32911689 http://dx.doi.org/10.3390/ijms21186561 |
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author | Krieger, Christine C. Neumann, Susanne Gershengorn, Marvin C. |
author_facet | Krieger, Christine C. Neumann, Susanne Gershengorn, Marvin C. |
author_sort | Krieger, Christine C. |
collection | PubMed |
description | In this review, we summarize the evidence against direct stimulation of insulin-like growth factor 1 receptors (IGF1Rs) by autoantibodies in Graves’ orbitopathy (GO) pathogenesis. We describe a model of thyroid-stimulating hormone (TSH) receptor (TSHR)/IGF1R crosstalk and present evidence that observations indicating IGF1R’s role in GO could be explained by this mechanism. We evaluate the evidence for and against IGF1R as a direct target of stimulating IGF1R antibodies (IGF1RAbs) and conclude that GO pathogenesis does not involve directly stimulating IGF1RAbs. We further conclude that the preponderance of evidence supports TSHR as the direct and only target of stimulating autoantibodies in GO and maintain that the TSHR should remain a major target for further development of a medical therapy for GO in concert with drugs that target TSHR/IGF1R crosstalk. |
format | Online Article Text |
id | pubmed-7555308 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-75553082020-10-19 Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis? Krieger, Christine C. Neumann, Susanne Gershengorn, Marvin C. Int J Mol Sci Review In this review, we summarize the evidence against direct stimulation of insulin-like growth factor 1 receptors (IGF1Rs) by autoantibodies in Graves’ orbitopathy (GO) pathogenesis. We describe a model of thyroid-stimulating hormone (TSH) receptor (TSHR)/IGF1R crosstalk and present evidence that observations indicating IGF1R’s role in GO could be explained by this mechanism. We evaluate the evidence for and against IGF1R as a direct target of stimulating IGF1R antibodies (IGF1RAbs) and conclude that GO pathogenesis does not involve directly stimulating IGF1RAbs. We further conclude that the preponderance of evidence supports TSHR as the direct and only target of stimulating autoantibodies in GO and maintain that the TSHR should remain a major target for further development of a medical therapy for GO in concert with drugs that target TSHR/IGF1R crosstalk. MDPI 2020-09-08 /pmc/articles/PMC7555308/ /pubmed/32911689 http://dx.doi.org/10.3390/ijms21186561 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Krieger, Christine C. Neumann, Susanne Gershengorn, Marvin C. Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis? |
title | Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis? |
title_full | Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis? |
title_fullStr | Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis? |
title_full_unstemmed | Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis? |
title_short | Is There Evidence for IGF1R-Stimulating Abs in Graves’ Orbitopathy Pathogenesis? |
title_sort | is there evidence for igf1r-stimulating abs in graves’ orbitopathy pathogenesis? |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555308/ https://www.ncbi.nlm.nih.gov/pubmed/32911689 http://dx.doi.org/10.3390/ijms21186561 |
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