Implications of the Orb2 Amyloid Structure in Huntington’s Disease

Huntington’s disease is a progressive, autosomal dominant, neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. As a result, the translated protein, huntingtin, contains an abnormally long polyglutamine stretch that makes it prone to misfold and aggregating. Aggregatio...

Descripción completa

Detalles Bibliográficos
Autores principales: Hervás, Rubén, Murzin, Alexey G., Si, Kausik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555547/
https://www.ncbi.nlm.nih.gov/pubmed/32967102
http://dx.doi.org/10.3390/ijms21186910

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555547/
https://www.ncbi.nlm.nih.gov/pubmed/32967102
http://dx.doi.org/10.3390/ijms21186910

Ejemplares similares