Distinct TP53 Mutation Types Exhibit Increased Sensitivity to Ferroptosis Independently of Changes in Iron Regulatory Protein Activity

The tumor suppressor gene TP53 is the most commonly mutated gene in human cancer. In addition to loss of tumor suppressor functions, mutations in TP53 promote cancer progression by altering cellular iron acquisition and metabolism. A newly identified role for TP53 in the coordination of iron homeost...

Descripción completa

Detalles Bibliográficos
Autores principales: Thompson, Laurie R., Oliveira, Thais G., Hermann, Evan R., Chowanadisai, Winyoo, Clarke, Stephen L., Montgomery, McKale R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555626/
https://www.ncbi.nlm.nih.gov/pubmed/32942535
http://dx.doi.org/10.3390/ijms21186751

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555626/
https://www.ncbi.nlm.nih.gov/pubmed/32942535
http://dx.doi.org/10.3390/ijms21186751

Ejemplares similares