P2 × 7 Receptor Inhibits Astroglial Autophagy via Regulating FAK- and PHLPP1/2-Mediated AKT-S473 Phosphorylation Following Kainic Acid-Induced Seizures

Recently, we have reported that blockade/deletion of P2X7 receptor (P2X7R), an ATP-gated ion channel, exacerbates heat shock protein 25 (HSP25)-mediated astroglial autophagy (clasmatodendrosis) following kainic acid (KA) injection. In P2X7R knockout (KO) mice, prolonged astroglial HSP25 induction ex...

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Detalles Bibliográficos
Autores principales: Lee, Duk-Shin, Kim, Ji-Eun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555659/
https://www.ncbi.nlm.nih.gov/pubmed/32899862
http://dx.doi.org/10.3390/ijms21186476

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555659/
https://www.ncbi.nlm.nih.gov/pubmed/32899862
http://dx.doi.org/10.3390/ijms21186476

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