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Hippuric Acid Promotes Renal Fibrosis by Disrupting Redox Homeostasis via Facilitation of NRF2–KEAP1–CUL3 Interactions in Chronic Kidney Disease
Chronic kidney disease (CKD) is characterized by the accumulation of protein-bound uremic toxins (PBUTs), which play a pathophysiological role in renal fibrosis (a common pathological process resulting in CKD progression). Accumulation of the PBUT hippuric acid (HA) is positively correlated with dis...
Autores principales: | Sun, Bowen, Wang, Xifan, Liu, Xiaoxue, Wang, Longjiao, Ren, Fazheng, Wang, Xiaoyu, Leng, Xiaojing |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555723/ https://www.ncbi.nlm.nih.gov/pubmed/32854194 http://dx.doi.org/10.3390/antiox9090783 |
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