Irisin Mitigates Oxidative Stress, Chondrocyte Dysfunction and Osteoarthritis Development through Regulating Mitochondrial Integrity and Autophagy

Compromised autophagy and mitochondrial dysfunction downregulate chondrocytic activity, accelerating the development of osteoarthritis (OA). Irisin, a cleaved form of fibronectin type III domain containing 5 (FNDC5), regulates bone turnover and muscle homeostasis. Little is known about the effect of...

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Detalles Bibliográficos
Autores principales: Wang, Feng-Sheng, Kuo, Chung-Wen, Ko, Jih-Yang, Chen, Yu-Shan, Wang, Shao-Yu, Ke, Huei-Jing, Kuo, Pei-Chen, Lee, Chin-Huei, Wu, Jian-Ching, Lu, Wen-Bin, Tai, Ming-Hong, Jahr, Holger, Lian, Wei-Shiung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555738/
https://www.ncbi.nlm.nih.gov/pubmed/32882839
http://dx.doi.org/10.3390/antiox9090810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555738/
https://www.ncbi.nlm.nih.gov/pubmed/32882839
http://dx.doi.org/10.3390/antiox9090810

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