Cargando…

The Role of Smoothened in Cancer

Smoothened (SMO) belongs to the Hedgehog (HH) signaling pathway, which regulates cell growth, migration, invasion and stem cells in cancer. The HH signaling pathway includes both canonical and noncanonical pathways. The canonical HH pathway functions through major HH molecules such as HH ligands, PT...

Descripción completa

Detalles Bibliográficos
Autores principales:	Jeng, Kuo-Shyang, Sheen, I-Shyan, Leu, Chuen-Miin, Tseng, Ping-Hui, Chang, Chiung-Fang
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555769/ https://www.ncbi.nlm.nih.gov/pubmed/32962123 http://dx.doi.org/10.3390/ijms21186863

Ejemplares similares

The Role of Endoglin in Hepatocellular Carcinoma
por: Jeng, Kuo-Shyang, et al.
Publicado: (2021)

Sonic Hedgehog signaling pathway as a potential target to inhibit the progression of hepatocellular carcinoma
por: Jeng, Kuo-Shyang, et al.
Publicado: (2019)

Upper Gastrointestinal Cancer and Liver Cirrhosis
por: Jeng, Kuo-Shyang, et al.
Publicado: (2022)

Cellular and Molecular Biology of Cancer Stem Cells of Hepatocellular Carcinoma
por: Jeng, Kuo-Shyang, et al.
Publicado: (2023)

Glioma-Associated Oncogene Homolog Inhibitors Have the Potential of Suppressing Cancer Stem Cells of Breast Cancer
por: Jeng, Kuo-Shyang, et al.
Publicado: (2018)

Towards Precision Oncology: The Role of Smoothened and Its Variants in Cancer
por: Nicheperovich, Alina, et al.
Publicado: (2022)

High expression of Sonic Hedgehog signaling pathway genes indicates a risk of recurrence of breast carcinoma
por: Jeng, Kuo-Shyang, et al.
Publicado: (2013)

Activation of the sonic hedgehog signaling pathway occurs in the CD133 positive cells of mouse liver cancer Hepa 1–6 cells
por: Jeng, Kuo-Shyang, et al.
Publicado: (2013)

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors
por: Pietrobono, Silvia, et al.
Publicado: (2018)

Response to inhibition of smoothened in diverse epithelial cancer cells that lack smoothened or patched 1 mutations
por: GALIMBERTI, FABRIZIO, et al.
Publicado: (2012)

Sonic Hedgehog Signaling in Organogenesis, Tumors, and Tumor Microenvironments
por: Jeng, Kuo-Shyang, et al.
Publicado: (2020)

The Role of Smoothened-Dependent and -Independent Hedgehog Signaling Pathway in Tumorigenesis
por: Chai, Jian Yi, et al.
Publicado: (2021)

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened
por: Gonnissen, Annelies, et al.
Publicado: (2015)

Mechanisms of Smoothened Regulation in Hedgehog Signaling
por: Zhang, Jie, et al.
Publicado: (2021)

Impact of the Smoothened Inhibitor, IPI-926, on Smoothened Ciliary Localization and Hedgehog Pathway Activity
por: Peluso, Marisa O., et al.
Publicado: (2014)

Contributions of Noncanonical Smoothened Signaling During Embryonic Development
por: Pandit, Tanushree, et al.
Publicado: (2017)

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors
por: Rimkus, Tadas K., et al.
Publicado: (2016)

Advanced basal cell carcinoma, the hedgehog pathway, and treatment options – role of smoothened inhibitors
por: Fecher, Leslie A, et al.
Publicado: (2015)

A Role for Smoothened during Murine Lens and Cornea Development
por: Choi, Janet J. Y., et al.
Publicado: (2014)

Functional Divergence in the Role of N-Linked Glycosylation in Smoothened Signaling
por: Marada, Suresh, et al.
Publicado: (2015)

An essential role for Grk2 in Hedgehog signalling downstream of Smoothened
por: Zhao, Zhonghua, et al.
Publicado: (2016)

Hedgehog pathway as a drug target: Smoothened inhibitors in development
por: Lin, Tara L, et al.
Publicado: (2012)

Genetic and Epigenetic Regulation of the Smoothened Gene (SMO) in Cancer Cells
por: Lou, Hong, et al.
Publicado: (2020)

Smoothened loss is a characteristic of neuroendocrine prostate cancer
por: Wang, Lili, et al.
Publicado: (2021)

Oxysterols are allosteric activators of the oncoprotein Smoothened
por: Nachtergaele, Sigrid, et al.
Publicado: (2012)

Smoothened as a new therapeutic target for human osteosarcoma
por: Hirotsu, Masataka, et al.
Publicado: (2010)

Structural insights into the role of the Smoothened cysteine-rich domain in Hedgehog signalling
por: Rana, Rajashree, et al.
Publicado: (2013)

Targeting Smoothened Sensitizes Gastric Cancer to Chemotherapy in Experimental Models
por: Ma, Huifa, et al.
Publicado: (2017)

Smoothened gene alterations in keratocystic odontogenic tumors
por: Rui, Zhang, et al.
Publicado: (2014)

Regulation of Smoothened Trafficking and Abundance in Hedgehog Signaling
por: Jia, Jianhang, et al.
Publicado: (2022)

Sonidegib, a novel smoothened inhibitor for the treatment of advanced basal cell carcinoma
por: Doan, Hung Q, et al.
Publicado: (2016)

Liver Fibrosis and Inflammation under the Control of ERK2
por: Jeng, Kuo-Shyang, et al.
Publicado: (2020)

Liver collision tumor of primary hepatocellular carcinoma and neuroendocrine carcinoma: A rare case report
por: Jeng, Kuo-Shyang, et al.
Publicado: (2022)

Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling
por: Qi, Xiaofeng, et al.
Publicado: (2020)

Roughing up Smoothened: chemical modulators of Hedgehog signaling
por: King, Randall W
Publicado: (2002)

Oxysterol binding to the extracellular domain of Smoothened in Hedgehog signaling
por: Nedelcu, Daniel, et al.
Publicado: (2013)

Dataset for phenotypic classification of genetic modifiers of smoothened and Hedgehog
por: Marada, Suresh, et al.
Publicado: (2016)

Structural basis for Smoothened regulation by its extracellular domains
por: Byrne, Eamon F.X., et al.
Publicado: (2016)

Identification of a potent antagonist of smoothened in hedgehog signaling
por: Fan, Junwan, et al.
Publicado: (2021)

A Potent Antagonist of Smoothened in Hedgehog Signaling for Epilepsy
por: Fan, Junwan, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_21habrphbq87dpdni2ij3u02dq