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Identification of Targets to Redirect CAR T Cells in Glioblastoma and Colorectal Cancer: An Arduous Venture

The chimeric antigen receptor (CAR) is an artificial molecule engineered to induce cytolytic T cell reactions in tumors. Generally, this molecule combines an extracellular single-chain variable fragment (scFv) able to recognize tumor-associated epitopes together with the intracellular signaling doma...

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Detalles Bibliográficos
Autores principales: Ponterio, Eleonora, De Maria, Ruggero, Haas, Tobias Longin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555836/
https://www.ncbi.nlm.nih.gov/pubmed/33101285
http://dx.doi.org/10.3389/fimmu.2020.565631