β(2)-AR blockade potentiates MEK1/2 inhibitor effect on HNSCC by regulating the Nrf2-mediated defense mechanism

The β2-Adrenergic receptor (β2-AR) is a G protein-coupled receptor (GPCR), involved in the development of many cancers, among which HNSCC. In this contest, β2-AR signaling interacts with different pathways, such as PI3K and MAPK, commonly activated by TK receptors. For this reason, TK blockade is on...

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Detalles Bibliográficos
Autores principales: Mele, Luigi, Del Vecchio, Vitale, Marampon, Francesco, Regad, Tarik, Wagner, Sarah, Mosca, Laura, Bimonte, Sabrina, Giudice, Aldo, Liccardo, Davide, Prisco, Claudia, Schwerdtfeger, Melanie, La Noce, Marcella, Tirino, Virginia, Caraglia, Michele, Papaccio, Gianpaolo, Desiderio, Vincenzo, Barbieri, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555890/
https://www.ncbi.nlm.nih.gov/pubmed/33051434
http://dx.doi.org/10.1038/s41419-020-03056-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555890/
https://www.ncbi.nlm.nih.gov/pubmed/33051434
http://dx.doi.org/10.1038/s41419-020-03056-x

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