Design and Validation of Linkers for Site-Specific Preparation of Antibody–Drug Conjugates Carrying Multiple Drug Copies Per Cysteine Conjugation Site

First-generation cysteine-based site-specific antibody–drug conjugates (ADCs) are limited to one drug per cysteine. However, certain applications require a high drug to antibody ratio (DAR), such as when low-potency payloads are used. Higher drug load can be achieved using classical cysteine conjuga...

Descripción completa

Detalles Bibliográficos
Autores principales: Kumar, Amit, Mao, Shenlan, Dimasi, Nazzareno, Gao, Changshou
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555909/
https://www.ncbi.nlm.nih.gov/pubmed/32961794
http://dx.doi.org/10.3390/ijms21186882

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555909/
https://www.ncbi.nlm.nih.gov/pubmed/32961794
http://dx.doi.org/10.3390/ijms21186882

Ejemplares similares