Withanolide Metabolites Inhibit PI3K/AKT and MAPK Pro-Survival Pathways and Induce Apoptosis in Acute Myeloid Leukemia Cells

Acute myeloid leukemia (AML) is an aggressive disease and, despite advances, its treatment remains challenging. Therefore, it remains important to identify new agents for the management of this disease. Withanolides, a group of steroidal lactones found in Solanaceae plants are of potential interest...

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Detalles Bibliográficos
Autores principales: Akhtar, Nosheen, Baig, Muhammad Waleed, Haq, Ihsan-ul, Rajeeve, Vinothini, Cutillas, Pedro Rodriguez
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555989/
https://www.ncbi.nlm.nih.gov/pubmed/32899914
http://dx.doi.org/10.3390/biomedicines8090333

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7555989/
https://www.ncbi.nlm.nih.gov/pubmed/32899914
http://dx.doi.org/10.3390/biomedicines8090333

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