Tofacitinib and Baricitinib Are Taken up by Different Uptake Mechanisms Determining the Efficacy of Both Drugs in RA

Background: Rheumatoid arthritis (RA) is a systemic autoimmune disease in which synovial fibroblasts (SF) play a key role. Baricitinib and Tofacitinib both act intracellularly, blocking the ATP-binding side of JAK proteins and thereby the downstream signalling pathway via STAT-3. Therefore, we inves...

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Detalles Bibliográficos
Autores principales: Amrhein, Jan, Drynda, Susanne, Schlatt, Lukas, Karst, Uwe, Lohmann, Christoph H., Ciarimboli, Giuliano, Bertrand, Jessica
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556031/
https://www.ncbi.nlm.nih.gov/pubmed/32927842
http://dx.doi.org/10.3390/ijms21186632

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556031/
https://www.ncbi.nlm.nih.gov/pubmed/32927842
http://dx.doi.org/10.3390/ijms21186632

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