The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity

APOBEC1 (APO1), a member of AID/APOBEC nucleic acid cytosine deaminase family, can edit apolipoprotein B mRNA to regulate cholesterol metabolism. This APO1 RNA editing activity requires a cellular cofactor to achieve tight regulation. However, no cofactors are required for deamination on DNA by APO1...

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Detalles Bibliográficos
Autores principales: Wolfe, Aaron D, Li, Shuxing, Goedderz, Cody, Chen, Xiaojiang S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Structural Biology of Cancer-Related Macromolecules
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556403/
https://www.ncbi.nlm.nih.gov/pubmed/33094286
http://dx.doi.org/10.1093/narcan/zcaa027

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556403/
https://www.ncbi.nlm.nih.gov/pubmed/33094286
http://dx.doi.org/10.1093/narcan/zcaa027

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