Cargando…

The structure of APOBEC1 and insights into its RNA and DNA substrate selectivity

APOBEC1 (APO1), a member of AID/APOBEC nucleic acid cytosine deaminase family, can edit apolipoprotein B mRNA to regulate cholesterol metabolism. This APO1 RNA editing activity requires a cellular cofactor to achieve tight regulation. However, no cofactors are required for deamination on DNA by APO1...

Descripción completa

Detalles Bibliográficos
Autores principales:	Wolfe, Aaron D, Li, Shuxing, Goedderz, Cody, Chen, Xiaojiang S
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Oxford University Press 2020
Materias:	Structural Biology of Cancer-Related Macromolecules
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556403/ https://www.ncbi.nlm.nih.gov/pubmed/33094286 http://dx.doi.org/10.1093/narcan/zcaa027

Ejemplares similares

Mechanism for APOBEC3G catalytic exclusion of RNA and non-substrate DNA
por: Solomon, William C, et al.
Publicado: (2019)

Problems of an RNA Genome Operating in a DNA-Dominated Biological Universe
por: Spiegelman, S., et al.
Publicado: (1966)

NMR-based method of small changes reveals how DNA mutator APOBEC3A interacts with its single-stranded DNA substrate
por: Harjes, Stefan, et al.
Publicado: (2017)

Structural determinants of APOBEC3B non-catalytic domain for molecular assembly and catalytic regulation
por: Xiao, Xiao, et al.
Publicado: (2017)

Polysaccharide Biosynthesis
por: Robbins, P. W., et al.
Publicado: (1966)

Problems in Protein Biosynthesis
por: Lengyel, Peter
Publicado: (1966)

Membrane Structure and Function
por: Kennedy, Eugene P., et al.
Publicado: (1966)

Contractility and Conformation
por: Scheraga, Harold A.
Publicado: (1967)

Some Fundamental Molecular Mechanisms of Contractility in Fibrous Macromolecules
por: Mandelkern, L.
Publicado: (1967)

Structural basis for acceptor RNA substrate selectivity of the 3′ terminal uridylyl transferase Tailor
por: Kroupova, Alena, et al.
Publicado: (2019)

EBV‐LMP1 induces APOBEC3s and mitochondrial DNA hypermutation in nasopharyngeal cancer
por: Wakae, Kousho, et al.
Publicado: (2020)

RusA Holliday junction resolvase: DNA complex structure—insights into selectivity and specificity
por: Macmaster, Rachel, et al.
Publicado: (2006)

Crystal structure of the catalytic core of Rad2: insights into the mechanism of substrate binding
por: Miętus, Michał, et al.
Publicado: (2014)

DapF stabilizes the substrate-favoring conformation of RppH to stimulate its RNA-pyrophosphohydrolase activity in Escherichia coli
por: Wang, Qiang, et al.
Publicado: (2018)

Mini-chromosome maintenance complexes form a filament to remodel DNA structure and topology
por: Slaymaker, Ian M., et al.
Publicado: (2013)

Molecular insight into the specific enzymatic properties of TREX1 revealing the diverse functions in processing RNA and DNA/RNA hybrids
por: Huang, Kuan-Wei, et al.
Publicado: (2023)

Structural basis of sequence-specific RNA recognition by the antiviral factor APOBEC3G
por: Yang, Hanjing, et al.
Publicado: (2022)

Structures of HIV-1 RT-RNA/DNA ternary complexes with dATP and nevirapine reveal conformational flexibility of RNA/DNA: insights into requirements for RNase H cleavage
por: Das, Kalyan, et al.
Publicado: (2014)

Structural basis for the substrate recognition and catalysis of peptidyl-tRNA hydrolase
por: Ito, Kosuke, et al.
Publicado: (2012)

Molecular mechanism of RNase R substrate sensitivity for RNA ribose methylation
por: Abula, Abudureyimu, et al.
Publicado: (2021)

Crystal structure of human polynucleotide phosphorylase: insights into its domain function in RNA binding and degradation
por: Lin, Chia Liang, et al.
Publicado: (2012)

Molecular insights into the interaction of CAG trinucleotide RNA repeats with nucleolin and its implication in polyglutamine diseases
por: An, Ying, et al.
Publicado: (2022)

Structural insights into catalytic and substrate binding mechanisms of the strategic EndA nuclease from Streptococcus pneumoniae
por: Moon, Andrea F., et al.
Publicado: (2011)

Structures of an engineered phospholipase D with specificity for secondary alcohol transphosphatidylation: insights into plasticity of substrate binding and activation
por: Samantha, Ariela, et al.
Publicado: (2021)

Characterization of the mechanism by which the RB/E2F pathway controls expression of the cancer genomic DNA deaminase APOBEC3B
por: Roelofs, Pieter A, et al.
Publicado: (2020)

Crystal structures of I-SceI complexed to nicked DNA substrates: snapshots of intermediates along the DNA cleavage reaction pathway
por: Moure, Carmen M., et al.
Publicado: (2008)

The crystal structure of Pyrococcus abyssi tRNA (uracil-54, C5)-methyltransferase provides insights into its tRNA specificity
por: Walbott, Hélène, et al.
Publicado: (2008)

X-ray structure of the fourth type of archaeal tRNA splicing endonuclease: insights into the evolution of a novel three-unit composition and a unique loop involved in broad substrate specificity
por: Hirata, Akira, et al.
Publicado: (2012)

Structural insights into the duplex DNA processing of TREX2
por: Cheng, Hiu-Lo, et al.
Publicado: (2018)

Insight into formation propensity of pseudocircular DNA G-hairpins
por: Živković, Martina Lenarčič, et al.
Publicado: (2021)

Structural insights into CodY activation and DNA recognition
por: Hainzl, Tobias, et al.
Publicado: (2023)

FHIT loss-induced DNA damage creates optimal APOBEC substrates: Insights into APOBEC-mediated mutagenesis
por: Waters, Catherine E., et al.
Publicado: (2014)

The Fanconi anemia associated protein FAAP24 uses two substrate specific binding surfaces for DNA recognition
por: Wienk, Hans, et al.
Publicado: (2013)

Structural insights into CpG-specific DNA methylation by human DNA methyltransferase 3B
por: Lin, Chien-Chu, et al.
Publicado: (2020)

Insights into DNA substrate selection by APOBEC3G from structural, biochemical, and functional studies
por: Ziegler, Samantha J., et al.
Publicado: (2018)

Insight into F plasmid DNA segregation revealed by structures of SopB and SopB–DNA complexes
por: Schumacher, Maria A., et al.
Publicado: (2010)

Structure of the N-glycosidase MilB in complex with hydroxymethyl CMP reveals its Arg23 specifically recognizes the substrate and controls its entry
por: Zhao, Gong, et al.
Publicado: (2014)

Structural insights into RNA unwinding and degradation by RNase R
por: Chu, Lee-Ya, et al.
Publicado: (2017)

Structural insights into the functions of the FANCM-FAAP24 complex in DNA repair
por: Yang, Hui, et al.
Publicado: (2013)

Structural insights into DNA degradation by human mitochondrial nuclease MGME1
por: Yang, Chun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_b30cbgiqprf5c4evgefnsjake5