Pharmacological Inhibition of PPARy Boosts HIV Reactivation and Th17 Effector Functions, While Preventing Progeny Virion Release and de novo Infection

The frequency and functions of Th17-polarized CCR6(+)RORyt(+)CD4(+) T cells are rapidly compromised upon HIV infection and are not restored with long-term viral suppressive antiretroviral therapy (ART). In line with this, Th17 cells represent selective HIV-1 infection targets mainly at mucosal sites...

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Detalles Bibliográficos
Autores principales: Planas, Delphine, Fert, Augustine, Zhang, Yuwei, Goulet, Jean-Philippe, Richard, Jonathan, Finzi, Andrés, Ruiz, Maria Julia, Marchand, Laurence Raymond, Chatterjee, Debashree, Chen, Huicheng, Wiche Salinas, Tomas Raul, Gosselin, Annie, Cohen, Eric A., Routy, Jean-Pierre, Chomont, Nicolas, Ancuta, Petronela
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Pathogens and Immunity 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556414/
https://www.ncbi.nlm.nih.gov/pubmed/33089034
http://dx.doi.org/10.20411/pai.v5i1.348

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556414/
https://www.ncbi.nlm.nih.gov/pubmed/33089034
http://dx.doi.org/10.20411/pai.v5i1.348

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