Quercetin potentializes the respective cytotoxic activity of gemcitabine or doxorubicin on 3D culture of AsPC-1 or HepG2 cells, through the inhibition of HIF-1α and MDR1

The impact of cancer on lifespan is significantly increasing worldwide. Enhanced activity of drug efflux pumps and the incidences of the tumor microenvironment such as the apparition of a hypoxic gradient inside of the bulk tumor, are the major causes of chemotherapy failure. For instance, expressio...

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Detalles Bibliográficos
Autores principales: Hassan, Sarah, Peluso, Jean, Chalhoub, Sandra, Idoux Gillet, Ysia, Benkirane-Jessel, Nadia, Rochel, Natacha, Fuhrmann, Guy, Ubeaud-Sequier, Genevieve
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556446/
https://www.ncbi.nlm.nih.gov/pubmed/33052979
http://dx.doi.org/10.1371/journal.pone.0240676

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556446/
https://www.ncbi.nlm.nih.gov/pubmed/33052979
http://dx.doi.org/10.1371/journal.pone.0240676

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