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Mycolactone induces cell death by SETD1B-dependent degradation of glutathione

Mycobacterium ulcerans is a human pathogen that causes a necrotizing skin disease known as Buruli ulcer. Necrosis of infected skin is driven by bacterial production of mycolactone, a diffusible exotoxin targeting the host translocon (Sec61). By blocking Sec61, mycolactone prevents the transport of n...

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Detalles Bibliográficos
Autores principales: Förster, Birgit, Demangel, Caroline, Thye, Thorsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556509/
https://www.ncbi.nlm.nih.gov/pubmed/33006969
http://dx.doi.org/10.1371/journal.pntd.0008709