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Mycolactone induces cell death by SETD1B-dependent degradation of glutathione
Mycobacterium ulcerans is a human pathogen that causes a necrotizing skin disease known as Buruli ulcer. Necrosis of infected skin is driven by bacterial production of mycolactone, a diffusible exotoxin targeting the host translocon (Sec61). By blocking Sec61, mycolactone prevents the transport of n...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Public Library of Science
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556509/ https://www.ncbi.nlm.nih.gov/pubmed/33006969 http://dx.doi.org/10.1371/journal.pntd.0008709 |