SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation

Epigenetic regulators play a critical role in normal and malignant hematopoiesis. Deregulation, including epigenetic deregulation, of the HOXA gene cluster drives transformation of about 50% of acute myeloid leukemia (AML). We recently showed that the histone 3 lysine 9 methyltransferase SETDB1 nega...

Descripción completa

Detalles Bibliográficos
Autores principales: Ropa, James, Saha, Nirmalya, Hu, Hsiangyu, Peterson, Luke F., Talpaz, Moshe, Muntean, Andrew G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556517/
https://www.ncbi.nlm.nih.gov/pubmed/33054052
http://dx.doi.org/10.3324/haematol.2019.223883

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556517/
https://www.ncbi.nlm.nih.gov/pubmed/33054052
http://dx.doi.org/10.3324/haematol.2019.223883

Ejemplares similares