Cargando…

SETDB1 mediated histone H3 lysine 9 methylation suppresses MLL-fusion target expression and leukemic transformation

Epigenetic regulators play a critical role in normal and malignant hematopoiesis. Deregulation, including epigenetic deregulation, of the HOXA gene cluster drives transformation of about 50% of acute myeloid leukemia (AML). We recently showed that the histone 3 lysine 9 methyltransferase SETDB1 nega...

Descripción completa

Detalles Bibliográficos
Autores principales:	Ropa, James, Saha, Nirmalya, Hu, Hsiangyu, Peterson, Luke F., Talpaz, Moshe, Muntean, Andrew G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Fondazione Ferrata Storti 2019
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556517/ https://www.ncbi.nlm.nih.gov/pubmed/33054052 http://dx.doi.org/10.3324/haematol.2019.223883

Ejemplares similares

The PAF Complex Regulation of Prmt5 Facilitates the Progression and Maintenance of MLL-Fusion Leukemia
por: Serio, Justin, et al.
Publicado: (2017)

PAF1 complex interactions with SETDB1 mediate promoter H3K9 methylation and transcriptional repression of Hoxa9 and Meis1 in acute myeloid leukemia
por: Ropa, James, et al.
Publicado: (2018)

The PAF1c Subunit CDC73 Is Required for Mouse Hematopoietic Stem Cell Maintenance but Displays Leukemia-Specific Gene Regulation
por: Saha, Nirmalya, et al.
Publicado: (2019)

MLL1 and MLL1 fusion proteins have distinct functions in regulating leukemic transcription program
por: Xu, Jing, et al.
Publicado: (2016)

The cytoplasmic fraction of the histone lysine methyltransferase Setdb1 is essential for embryonic stem cells
por: Rapone, Roberta, et al.
Publicado: (2023)

Deficiency of histone lysine methyltransferase SETDB2 in hematopoietic cells promotes vascular inflammation and accelerates atherosclerosis
por: Zhang, Xinbo, et al.
Publicado: (2021)

Zoledronic acid inhibits the growth of leukemic MLL-AF9 transformed hematopoietic cells
por: Chiarella, Emanuela, et al.
Publicado: (2020)

RNA Polymerase II-Dependent Transcription Initiated by Selectivity Factor 1: A Central Mechanism Used by MLL Fusion Proteins in Leukemic Transformation
por: Yokoyama, Akihiko
Publicado: (2019)

MLL2 Is Required in Oocytes for Bulk Histone 3 Lysine 4 Trimethylation and Transcriptional Silencing
por: Andreu-Vieyra, Claudia V., et al.
Publicado: (2010)

The histone 3 lysine 4 methyltransferase, Mll2, is only required briefly in development and spermatogenesis
por: Glaser, Stefan, et al.
Publicado: (2009)

Ubiquitination of Lysine 867 of the Human SETDB1 Protein Upregulates Its Histone H3 Lysine 9 (H3K9) Methyltransferase Activity
por: Ishimoto, Kenji, et al.
Publicado: (2016)

Hematopoietic Stem Cell (HSC)-Independent Progenitors Are Susceptible to Mll-Af9-Induced Leukemic Transformation
por: Barone, Cristiana, et al.
Publicado: (2023)

Histone lysine methyltransferase SETDB2 suppresses NRF2 to restrict tumor progression and modulates chemotherapy sensitivity in lung adenocarcinoma
por: Yuan, Guangda, et al.
Publicado: (2022)

Targeting the histone H3 lysine 79 methyltransferase DOT1L in MLL-rearranged leukemias
por: Yi, Yan, et al.
Publicado: (2022)

SET1/MLL family of proteins: functions beyond histone methylation
por: Sugeedha, Jeyapal, et al.
Publicado: (2020)

The SETDB1 histone methyltransferase is recurrently amplified in and accelerates melanoma
por: Ceol, Craig J., et al.
Publicado: (2011)

Oncogenic roles of the SETDB2 histone methyltransferase in gastric cancer
por: Nishikawaji, Taketo, et al.
Publicado: (2016)

Hepatocellular SETDB1 Regulates Hepatic Ischemia-Reperfusion Injury through Targeting Lysine Methylation of ASK1 Signal
por: Xia, Kang, et al.
Publicado: (2023)

Histone Lysine Methylation in Diabetic Nephropathy
por: Sun, Guang-dong, et al.
Publicado: (2014)

Histone Lysine Methylation and Neurodevelopmental Disorders
por: Kim, Jeong-Hoon, et al.
Publicado: (2017)

Histone methyltransferase SETDB1 regulates liver cancer cell growth through methylation of p53
por: Fei, Qi, et al.
Publicado: (2015)

Low-dose salinomycin induces anti-leukemic responses in AML and MLL
por: Roulston, Gary D.R., et al.
Publicado: (2016)

Association of the histone-lysine N-methyltransferase MLL5 gene with coronary artery disease in Chinese Han people
por: Yuan, Qinghua, et al.
Publicado: (2014)

Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis
por: Grigsby, Sierrah M., et al.
Publicado: (2021)

Role of histone methyltransferase SETDB1 in regulation of tumourigenesis and immune response
por: Zhao, Zhipeng, et al.
Publicado: (2022)

Writing, erasing and reading histone lysine methylations
por: Hyun, Kwangbeom, et al.
Publicado: (2017)

Intrinsic protein disorder in histone lysine methylation
por: Lazar, Tamas, et al.
Publicado: (2016)

Understanding the relationship between DNA methylation and histone lysine methylation()
por: Rose, Nathan R., et al.
Publicado: (2014)

Discovery of first-in-class inhibitors of ASH1L histone methyltransferase with anti-leukemic activity
por: Rogawski, David S., et al.
Publicado: (2021)

ΔNp63α modulates histone methyl transferase SETDB1 to transcriptionally repress target genes in cancers
por: Regina, C, et al.
Publicado: (2016)

Gene amplification of the histone methyltransferase SETDB1 contributes to human lung tumorigenesis
por: Rodriguez-Paredes, M, et al.
Publicado: (2014)

A somatic role for the histone methyltransferase Setdb1 in endogenous retrovirus silencing
por: Kato, Masaki, et al.
Publicado: (2018)

Crosstalk between NSL Histone Acetyltransferase and MLL/SET Complexes: NSL Complex Functions in Promoting Histone H3K4 Di-Methylation Activity by MLL/SET Complexes
por: Zhao, Xiaoming, et al.
Publicado: (2013)

Tackling malignant melanoma epigenetically: histone lysine methylation
por: Orouji, Elias, et al.
Publicado: (2018)

Phase Separation Mediates NUP98 Fusion Oncoprotein Leukemic Transformation
por: Chandra, Bappaditya, et al.
Publicado: (2022)

Hypomethylation of ERVs in the sperm of mice haploinsufficient for the histone methyltransferase Setdb1 correlates with a paternal effect on phenotype
por: Daxinger, Lucia, et al.
Publicado: (2016)

Ets1 Plays a Critical Role in MLL/EB1-Mediated Leukemic Transformation in a Mouse Bone Marrow Transplantation Model
por: Fu, Jen-Fen, et al.
Publicado: (2019)

ZNF274 Recruits the Histone Methyltransferase SETDB1 to the 3′ Ends of ZNF Genes
por: Frietze, Seth, et al.
Publicado: (2010)

Histone methyltransferase SETDB1 is required for prostate cancer cell proliferation, migration and invasion
por: Sun, Yi, et al.
Publicado: (2014)

Cancer cells, on your histone marks, get SETDB1, silence retrotransposons, and go!
por: Robbez-Masson, Luisa, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_nq7ld5ti3ivfqgnra0kdn5ii9a