A mutated factor X activatable by thrombin corrects bleedings in vivo in a rabbit model of antibody-induced hemophilia A

Rendering coagulation factor X sensitive to thrombin was proposed as a strategy to bypass the need for factor VIII. In this study, this nonreplacement strategy was evaluated in vitro and in vivo for its ability to correct factor VIII but also factor IX, X and XI deficiencies. A novel modified factor...

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Detalles Bibliográficos
Autores principales: Abache, Toufik, Fontayne, Alexandre, Grenier, Dominique, Jacque, Emilie, Longue, Alain, Dezetter, Anne-Sophie, Souilliart, Béatrice, Chevreux, Guillaume, Bataille, Damien, Chtourou, Sami, Plantier, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556615/
https://www.ncbi.nlm.nih.gov/pubmed/33054058
http://dx.doi.org/10.3324/haematol.2019.219865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556615/
https://www.ncbi.nlm.nih.gov/pubmed/33054058
http://dx.doi.org/10.3324/haematol.2019.219865

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