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A mutated factor X activatable by thrombin corrects bleedings in vivo in a rabbit model of antibody-induced hemophilia A
Rendering coagulation factor X sensitive to thrombin was proposed as a strategy to bypass the need for factor VIII. In this study, this nonreplacement strategy was evaluated in vitro and in vivo for its ability to correct factor VIII but also factor IX, X and XI deficiencies. A novel modified factor...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Fondazione Ferrata Storti
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556615/ https://www.ncbi.nlm.nih.gov/pubmed/33054058 http://dx.doi.org/10.3324/haematol.2019.219865 |