RAL GTPases mediate multiple myeloma cell survival and are activated independently of oncogenic RAS

Oncogenic RAS provides crucial survival signaling for up to half of multiple myeloma (MM) cases, but has so far remained a clinically undruggable target. RAS-like protein (RAL) is a member of the RAS superfamily of small GTPases and is considered to be a potential mediator of oncogenic RAS signaling...

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Detalles Bibliográficos
Autores principales: Seibold, Marcel, Stühmer, Thorsten, Kremer, Nadine, Mottok, Anja, Scholz, Claus-Jürgen, Schlosser, Andreas, Leich, Ellen, Holzgrabe, Ulrike, Brünnert, Daniela, Barrio, Santiago, Kortüm, K. Martin, Solimando, Antonio G., Chatterjee, Manik, Einsele, Hermann, Rosenwald, Andreas, Bargou, Ralf C., Steinbrunn, Torsten
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556628/
https://www.ncbi.nlm.nih.gov/pubmed/33054056
http://dx.doi.org/10.3324/haematol.2019.223024

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556628/
https://www.ncbi.nlm.nih.gov/pubmed/33054056
http://dx.doi.org/10.3324/haematol.2019.223024

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