Murine tissue factor disulfide mutation causes a bleeding phenotype with sex specific organ pathology and lethality

Tissue factor (TF) is highly expressed in sub-endothelial tissue. The extracellular allosteric disulfide bond Cys186–Cys209 of human TF shows high evolutionary conservation and in vitro evidence suggests that it significantly contributes to TF procoagulant activity. To investigate the role of this a...

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Detalles Bibliográficos
Autores principales: Sluka, Susanna H. M., Stämpfli, Simon F., Akhmedov, Alexander, Rodewald, Tanja Klein, Sanz-Moreno, Adrián, Horsch, Marion, Grest, Paula, Rothmeier, Andrea S., Rathkolb, Birgit, Schrewe, Anja, Beckers, Johannes, Neff, Frauke, Wolf, Eckhard, Camici, Giovanni G., Fuchs, Helmut, Durner, Valerie Gailus, de Angelis, Martin Hrabě, Lüscher, Thomas F., Ruf, Wolfram, Tanner, Felix C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556672/
https://www.ncbi.nlm.nih.gov/pubmed/33054088
http://dx.doi.org/10.3324/haematol.2019.218818

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556672/
https://www.ncbi.nlm.nih.gov/pubmed/33054088
http://dx.doi.org/10.3324/haematol.2019.218818

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