Repurposing pyridoxamine for therapeutic intervention of intravascular cell-cell interactions in mouse models of sickle cell disease

Adherent neutrophils on vascular endothelium positively contribute to cell-cell aggregation and vaso-occlusion in sickle cell disease (SCD). In the present study, we demonstrated that pyridoxamine, a derivative of vitamin B6, might be a therapeutic agent to alleviate intravascular cell-cell aggregat...

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Detalles Bibliográficos
Autores principales: Li, Jing, Jeong, Si-Yeon, Xiong, Bei, Tseng, Alan, Mahon, Andrew B., Isaacman, Steven, Gordeuk, Victor R., Cho, Jaehyung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556679/
https://www.ncbi.nlm.nih.gov/pubmed/33054081
http://dx.doi.org/10.3324/haematol.2019.226720

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556679/
https://www.ncbi.nlm.nih.gov/pubmed/33054081
http://dx.doi.org/10.3324/haematol.2019.226720

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