Dominant negative Gfi1b mutations cause moderate thrombocytopenia and an impaired stress thrombopoiesis associated with mild erythropoietic abnormalities in mice

GFI1B-related thrombocytopenia (GFI1B-RT) is a rare bleeding disorder mainly caused by the presence of truncated GFI1B proteins with dominant-negative properties. The disease is characterized by low platelet counts, the presence of abnormal platelets, a megakaryocytic expansion, and mild erythroid d...

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Detalles Bibliográficos
Autores principales: Beauchemin, Hugues, Shooshtharizadeh, Peiman, Pinder, Jordan, Dellaire, Graham, Möröy, Tarik
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Fondazione Ferrata Storti 2019
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556681/
https://www.ncbi.nlm.nih.gov/pubmed/33054086
http://dx.doi.org/10.3324/haematol.2019.222596

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556681/
https://www.ncbi.nlm.nih.gov/pubmed/33054086
http://dx.doi.org/10.3324/haematol.2019.222596

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