cGAS suppresses genomic instability as a decelerator of replication forks

The cyclic GMP-AMP synthase (cGAS), a sensor of cytosolic DNA, is critical for the innate immune response. Here, we show that loss of cGAS in untransformed and cancer cells results in uncontrolled DNA replication, hyperproliferation, and genomic instability. While the majority of cGAS is cytoplasmic...

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Detalles Bibliográficos
Autores principales: Chen, Hao, Zhang, Jiamin, Wang, Yumin, Simoneau, Antoine, Yang, Hui, Levine, Arthur S., Zou, Lee, Chen, Zhijian, Lan, Li
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556829/
https://www.ncbi.nlm.nih.gov/pubmed/33055160
http://dx.doi.org/10.1126/sciadv.abb8941

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7556829/
https://www.ncbi.nlm.nih.gov/pubmed/33055160
http://dx.doi.org/10.1126/sciadv.abb8941

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